The Brazilian wandering spider is one of the most dangerous spiders known to man. It's venom contains a potent neurotoxin, known as PhTx3, which acts as a broad-spectrum calcium channel blocker that inhibits glutamate release, calcium uptake and also glutamate uptake in neural synapses. At deadly concentrations, this neurotoxin causes loss of muscle control and breathing problems, resulting in paralysis and eventual asphyxiation. In addition, the venom causes intense pain and inflammation following a bite due to an excitatory effect the venom has on the serotin 5-HT4 receptors of sensory nerves. This sensory nerve stimulation causes a release of neuropeptides such as substance P which triggers inflammation and pain. Thankfully there is an anti venom so not many fatalities occur.
No comments:
Post a Comment